lamivudine and zidovudine
CONSUMER MEDICINE INFORMATION
What’s on this leaflet
Please learn this leaflet fastidiously earlier than you begin LAMIVUDINE/ZIDOVUDINE VIATRIS
150/300. This leaflet solutions some widespread questions on LAMIVUDINE/ZIDOVUDINE VIATRIS
150/300.
It doesn’t include all of the out there data. It doesn’t take the place of speaking
to your physician or pharmacist.
All medicines have dangers and advantages. Your physician has weighed the dangers of you taking
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 in opposition to the advantages they anticipate it would have
on you.
When you’ve got any considerations about taking this medication, speak to your physician or pharmacist.
Preserve this leaflet along with your medication.
Chances are you’ll have to learn it once more.
What LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300 is used for
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 incorporates lamivudine and zidovudine which belongs
to a gaggle of medicines referred to as antiretrovirals.
Please notice that lamivudine is on the market as a stand alone pill (as LAMIVUDINE VIATRIS
150/300 lamivudine 150mg & 300mg tablets).
Lamivudine with zidovudine is used alone or with different antiretrovirals, to decelerate
the progressing of human immunodeficiency virus (HIV) an infection, which might result in
Acquired Immune Deficiency Syndrome (AIDS) and different associated diseases (e.g. AIDS-related
Complicated or ARC).
Lamivudine with zidovudine doesn’t remedy AIDS or HIV an infection, however slows manufacturing
of human immunodeficiency virus. On this means it stops ongoing harm to the physique’s
immune system, which fights an infection.
Lamivudine with zidovudine doesn’t cut back the danger of passing HIV an infection to others.
You possibly can nonetheless move on the HIV virus when taking this medication, though the danger is
lowered by efficient antiretroviral remedy. Talk about along with your physician the precautions
wanted to keep away from infecting different folks.
Whereas taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 and/or some other remedy for HIV
illness, it’s possible you’ll proceed to develop different infections and different issues of HIV
an infection. You need to preserve in common contact with the physician. The long-term dangers
and advantages of taking lamivudine / zidovudine mixture tablets usually are not recognized.
Your physician could have prescribed LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 for one more
purpose. Ask your physician when you’ve got any questions on why it has been prescribed
for you.
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 isn’t addictive.
Earlier than you are taking LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300
When you need to not take them
Don’t take LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 when you’ve got an allergy to:
any medication containing lamivudine
any medication containing zidovudine or
any of the elements listed on the finish of this leaflet.
Signs of an allergic response could also be delicate or extreme. They normally embody some
or all the following: wheezing, swelling of the lips/mouth, issue in respiratory,
hay fever, lumpy rash (“hives”) or fainting.
Don’t take LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 in case you are pregnant or breastfeeding,
except your physician says it is best to.
Your physician ought to focus on with you the dangers and advantages of utilizing LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300 in case you are pregnant or breast feeding.
Don’t take LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 when you’ve got.
Kidney illness
Liver illness
Decreased pink blood cell depend (anaemia),
Decreased white blood cell depend (neutropenia).
When you’ve got sure well being situations, you physician could advise that you simply take a decrease
dose of lamivudine and/or zidovudine, the energetic elements in LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300 tablets.
Lamivudine and zidovudine can be found as separate dosage kinds. Ask your physician
in case you are unsure whether or not it is best to take LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300.
Don’t take LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 after the expiry date (EXP) printed
on the pack.
In case you take them after the expiry date has handed, it might not work as nicely.
Don’t take LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 if the packaging is torn or exhibits
indicators of tampering.
In case you’re unsure whether or not you need to be taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300
speak to your physician.
Earlier than you begin to take them
You will need to inform your physician if:
you might be allergic to some other medicines, meals, preservatives or dyes.
You take or have taken some other medicines.
You have got, or have ever had, hepatitis B an infection.
You have got, or ever had, liver issues.
Whenever you cease taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300
When you’ve got a long-standing viral an infection of your liver (hepatitis B) it might flare
up. This may trigger severe sickness significantly in case your liver is already not working
very nicely. When you’ve got each HIV and hepatitis B, if you cease taking your LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300, your physician is more likely to organize exams now and again to test
how nicely your liver is working and to measure virus ranges.
Taking different medicines
Inform your physician or pharmacist in case you are taking some other medicines, together with any
that you simply get and not using a prescription from a pharmacy, grocery store or well being meals store.
In case you take ribavirin and LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 collectively it might trigger
or worsen anaemia. Please contact your physician in case you discover signs of anaemia (such
as tiredness and shortness of breath). Your physician will advise you whether or not it is best to
cease taking LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300.
There may be little details about the best way different medicines may have an effect on the best way LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300 works, or how LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 impacts different
medicines.
Explicit care is required when taking the painkiller, paracetamol.
Your physician or pharmacist will have the ability to let you know what to do when taking LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300 with different medicines.
Inform your physician in case you are taking any of the medicines under:
Ribavirin, paracetamol
Phenytoin, oxazepam, lorazepam.
Aspirin, codeine, morphine, methadone, rifampicin, indometacin, ketoprofen, naproxen,
cimetidine, clofibrate, probenecid.
Pentamidine, pyrimethamine, dapsone, atovaquone, amphotericin B (amphotericin), flucytosine,
ganciclovir, interferon, trimethoprim, sulfamethoxazole, clarithromycin.
Vincristine, vinblastine and doxorubicin.
Aciclovir, inosine pranobex, adriamycin, ciprofloxacin
Stavudine, zalcitabine or emtricibine
Sorbitol-containing medicines (normally liquids) used recurrently.
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 shouldn’t be taken with stavudine or zalcitabine
Use in youngsters
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 isn’t really helpful to be used in youngsters underneath
12 years of age. As a result of it’s a mounted dose mixture pill it can’t be adjusted
in keeping with the dimensions and weight of the affected person.
The way to take LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300
Your physician will inform you could have many LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 to take
and the way usually to take them. Additionally, you will discover this data on the label of your
medication.
Observe all instructions given to you by your physician or pharmacist fastidiously.
They might differ from the knowledge contained on this leaflet.
If you don’t perceive the directions on the field, ask your physician or pharmacist
for assist.
How a lot to take
The standard dosage of LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 is one pill twice a day.
The way to take them
Swallow the LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300 entire with a full glass of water.
Don’t divide.
When to take them
Your physician or pharmacist will have the ability to let you know when it is best to take your LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300 tablets.
How lengthy to take them
As a result of your medication helps to regulate your situation, however doesn’t remedy it, you’ll
have to take the tablets on daily basis. Don’t cease taking your medication with out first
speaking to your physician.
In case you overlook to take them
Whether it is nearly time in your subsequent dose, skip the dose you missed and take your subsequent
dose if you find yourself meant to. In any other case, take it as quickly as you bear in mind, then return
to taking it as you’ll usually.
Don’t take a double dose to make up for the dose you missed.
In case you take an excessive amount of (overdose)
Instantly phone your physician or the Poisons Info Centre (phone 13
11 26) for recommendation, or go to Accident and Emergency on the nearest hospital, in case you
suppose that you simply or anybody else could have taken an excessive amount of LAMIVUDINE/ ZIDOVUDINE VIATRIS
150/300. Do that even when there aren’t any indicators of discomfort or poisoning.
Chances are you’ll want pressing medical consideration.
Preserve phone numbers for these locations useful.
In case you are unsure what to do contact your physician or pharmacist.
If you are utilizing LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300
Issues you need to do
In case you are about to be began on any new medication, remind your physician and pharmacist
that you’re taking LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300.
There may be little details about the best way different medicines may have an effect on the best way that
LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300 works. You will need to inform your physician or pharmacist
that you’re taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 earlier than you begin taking
medicines you purchase from a pharmacy, well being meals store or grocery store. That is particularly
essential relating to medicines which could impact the kidneys, liver, pink
or white blood cells or different physique cells.
Inform your physician in case you turn into pregnant or are attempting to turn into pregnant.
Inform your physician if, for any purpose, you haven’t taken your medication precisely as prescribed.
In any other case, your physician might imagine that it was not efficient and alter your therapy
unnecessarily.
Issues you need to not do
Don’t cease taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 or change the dosage with out
checking along with your physician.
Don’t give LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300 to anybody else, even when they’ve
the identical situation as you.
Don’t take LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 to deal with some other complaints except
your physician tells you to.
Don’t give this medication to youngsters underneath 12 years of age. As a result of it’s a mounted
dose mixture pill it can’t be adjusted in keeping with the dimensions and weight of
the affected person.
Issues to watch out of
Watch out driving or working equipment till you understand how LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300 impacts you.
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 taken alone usually don’t trigger any issues
along with your skill to drive a automotive or function equipment. Nevertheless, as with many different
medicines, LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 could trigger headache and tiredness
in some folks.
Negative effects
Test along with your physician or pharmacist as quickly as attainable if you don’t really feel nicely whereas
you’re taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300, even in case you suppose that the issues
usually are not linked with the medication or usually are not listed on this leaflet.
Like all medicines, LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 could cause some unintended effects.
In the event that they happen, they’re more than likely to be minor and short-term. Nevertheless, some could also be
severe and wish medical consideration.
Probably the most severe unintended effects embody:
Decreased pink blood cell depend (anaemia).
Decreased white blood cell depend (neutropenia).
The frequency and severity of anaemia and neutropenia are higher in sufferers with
superior HIV illness, or in sufferers who begin taking LAMIVUDINE/ZIDOVUDINE VIATRIS
150/300 within the later levels of HIV illness.
If you are taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300, it is extremely essential that
your physician retains a detailed test in your well being and takes blood samples to watch
ranges of pink and white blood cells. In case you develop anaemia or neutropenia, your physician
could cut back or cease the dose of LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300, or suggest
customary therapy for these situations. As your physician any questions which you’ll
have.
It isn’t recognized whether or not many of those unintended effects are as a consequence of taking LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300 or taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 whereas taking different
medicines. A few of these signs could happen as a part of HIV an infection, AIDS and AIDS-related
Complicated.
The unintended effects listed under have been reported:
Physique odour, sweating, chills, swelling of lips and/or tongue, flu-like signs, fever,
elevated sensitivity to ache, again ache, enlarged glands, chest ache, weak point, weight
loss, usually feeling unwell, breast enlargement in male sufferers.
Widening of blood vessels, presumably resulting in low blood strain or feeling faint.
Constipation, issue in swallowing, gasoline from abdomen or bowel, diarrhoea, bleeding
gums or nostril, blood in stools, mouth ulcers, heartburn, vomiting, loss or discount
in urge for food, nausea.
Stomach discomfort or ache.
Muscle aches or pains, muscle shaking or spasm or twitching, muscle illness.
Enlarged fatty liver, irregular outcomes of blood exams of liver operate, irritation
of the pancreas.
Confusion, melancholy, nervousness, fainting, lack of psychological readability, dizziness, seizures,
extreme headache, sleeplessness, fatigue/tiredness.
Cough, sore throat, hay fever, sinus issues, hoarseness, change to notion of
style.
Pimples, itchiness, pores and skin rash, adjustments in nail, pores and skin or mouth color.
Imaginative and prescient issues, listening to loss, sensitivity to mild.
Passing an excessive amount of urine, ache, issue or elevated frequency of passing urine.
Discount in all blood cells.
Elevated bruising or bleeding.
Blood chemistry adjustments, with extra acidity of the blood.
Uncommon emotions in any a part of the physique, resembling numbness, burning, tingling or pins
and needles.
Hair loss.
Adjustments in fats distribution have been reported in affiliation with mixture antiretroviral
remedy. These could embody:
Lack of physique fats from areas resembling legs, arms and face.
Elevated fats showing in areas resembling stomach (stomach) and different inner organs,
breasts and the again of the neck.
Throughout the first few weeks of therapy with anti-HIV medicines, some folks, significantly
these which have been HIV optimistic for a while, could develop inflammatory reactions
(eg, ache, redness, swelling, excessive temperature) which can resemble an an infection and
could also be extreme. It’s thought that these reactions are attributable to a restoration within the
physique’s skill to struggle infections, beforehand suppressed by HIV. In case you turn into involved
about any of the brand new signs, or any adjustments in your well being after beginning HIV therapy,
please focus on along with your physician instantly.
Ask your physician or pharmacist to reply any questions you will have. In case you expertise
any of those unintended effects, and so they concern you, see your physician or pharmacist.
In case you suppose you might be having an allergic response to LAMIVUDINE/ZIDOVUDINE VIATRIS
150/300, TELL YOUR DOCTOR IMMEDIATELY or go to the closest Accident and Emergency
division at your nearest hospital. Signs normally embody some or all the following:
Wheezing
Swelling of the lips/mouth
Problem in respiratory
Hay fever
Lumpy rash (“hives”)
Fainting
When you’ve got any of the next signs quickly after beginning to take your medication,
DO NOT TAKE ANY MORE LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 and inform your physician IMMEDIATELY
or go to the closest accident and emergency division at your nearest hospital:
Extreme abdomen ache or cramps.
Nausea.
Vomiting.
These unintended effects could also be as a consequence of a situation referred to as pancreatitis.
In case you are on medicine for HIV and turn into very sick, with quick respiratory, cease taking
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 and seek the advice of your physician instantly. Chances are you’ll
have a situation generally known as “lactic acidosis”. The quick respiratory is because of excessive acid
ranges within the blood. Your liver is probably not working correctly and will get massive and fatty.
This may be life threatening. This sickness happens extra usually in girls than males.
See your physician in case you really feel usually unwell with a lack of urge for food, nausea, vomiting,
itching, yellowness of the pores and skin or eyes or darkish colored urine, or if the blood exams
of your liver operate are irregular. It’s probably you’ll have to cease taking LAMIVUDINE/ZIDOVUDINE
VIATRIS 150/300 tablets.
This isn’t a whole record of all attainable unintended effects. Others could happen in some
folks and there could also be some unintended effects not but recognized.
Negative effects could rely upon whether or not you are taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300
alone, or even have taken different antiretroviral medicine(s). Much less is thought about
attainable unintended effects of taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 with different antiretrovirals.
Inform your physician in case you discover the rest that’s making you are feeling unwell, even
if it isn’t on this record.
Ask your physician or pharmacist in case you do not perceive something on this record.
Don’t be alarmed by this record of attainable unintended effects. Chances are you’ll not expertise any
of them.
After utilizing LAMIVUDINE/ ZIDOVUDINE VIATRIS 150/300 tablets
Storage
Preserve this medication the place youngsters can not attain it.
A locked cabinet at the very least one-and-a-half metres above the bottom is an efficient place
to retailer medicines.
Preserve your tablets in a cool dry place the place the temperature stays under 30°C.
Don’t retailer LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 or some other medication within the toilet
or close to a sink. Don’t go away it on a window sill or within the automotive.
Warmth and dampness can destroy some medicines.
Preserve your tablets within the bottle till it’s time to take them.
In case you take the tablets out of the bottle they could not preserve nicely.
Disposal
In case your physician tells you to cease taking LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 or the
expiry date has handed, ask your pharmacist what to do with any tablets left over.
Product description
What it appears to be like like
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 is a white to off-white, capsule formed, biconvex
movie coated pill, debossed with “M” on left of the scoreline and “103” on proper,
on one facet and scored on the opposite facet.
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 is equipped in 60 pill bottles.
Elements
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 incorporates 150 mg of lamivudine and 300 mg of
zidovudine because the energetic ingredient.
It additionally incorporates the next inactive elements:
Microcrystalline cellulose.
Sodium starch glycollate sort A.
Magnesium stearate.
Colloidal anhydrous silica.
Propylene glycol (movie coating).
Opadry Full Movie Coating System 03H58736 White (ARTG PI No: 106640).
Provider
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 is equipped in Australia by:
Alphapharm Pty Ltd buying and selling as Viatris
Stage 1, 30 The Bond
30-34 Hickson Street
Millers Level NSW 2000
Cellphone: 1800 274 276
Australian registration numbers:
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300 bottle:
AUST R 167477
This leaflet was ready in September 2022.
LAMIVUDINE/ZIDOVUDINE VIATRIS 150/300_cmiSep22/00
